The active form of peptic ulcer / bleeding or recurrent peptic ulcer / bleeding history (two or more distinct episodes of established ulceration or bleeding).
III trimester of pregnancy.
Like other NSAIDs, diclofenac is also contraindicated in patients in whom the use of ibuprofen, aspirin or other nonsteroidal anti-inflammatory drugs provoke attacks of asthma, angioedema, urticaria or acute rhinitis.
Inflammatory bowel disease (e.g. Crohn's disease or ulcerative colitis).
Congestive heart failure (NYHAII-IV).
High risk of postoperative bleeding, no blood coagulation, hemostasis disorders, hematopoietic disorders or cerebrovascular bleeding.
Treatment of perioperative pain in coronary artery bypass grafting (or the use of heart-lung machine).
Coronary heart disease in patients with angina pectoris, myocardial infarction.
Cerebrovascular disease in patients who have had a stroke or have episodes of transient ischemic attacks. Peripheral Arterial Disease.
This dosage form of the drug is contraindicated in children.
For intravenous use only.
Concomitant use of NSAIDs or anticoagulants (including low-dose heparin).
In anamnesis: bleeding diathesis, confirmed or suspected cerebrovascular bleeding history.
The operations associated with high risk of bleeding.
Bronchial asthma in anamnesis.
Moderate or severe impairment of renal function (serum creatinine; 160 micromoles / L).
Hypovolemia or dehydration from any cause.